Optimization of a pyrazolo [1, 5-a] pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics

ME Fraley, RS Rubino, WF Hoffman…

文献索引：Bioorganic and medicinal chemistry letters, , vol. 12, # 24 p. 3537 - 3541

全文：HTML全文

被引用次数: 78

摘要

... Bioorganic & Medicinal Chemistry Letters. ... Departments of Medicinal Chemistry and Cancer ... The chemistry in the 3-phenyl series involved oxidation of the corresponding 4-pyridyl ring followed by rearrangement of the resulting pyridine n-oxide under standard conditions ...