Tetrahedron

(2S, 5R/2R, 5S)-Aminoethylpipecolyl aepip-aegPNA chimera: synthesis and duplex/triplex stability

PS Shirude, VA Kumar, KN Ganesh

文献索引：Shirude, Pravin S.; Kumar, Vaijayanti A.; Ganesh, Krishna N. Tetrahedron, 2004 , vol. 60, # 42 p. 9485 - 9491

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被引用次数: 18

摘要

This article reports the design and facile synthesis of novel chiral six-membered PNA analogues (2S, 5R/2R, 5S)-1-(N-Boc-aminoethyl)-5-(thymin-1-yl) pipecolic acid, aepipPNA that upon incorporation into standard aegPNA sequences effected stabilization of complexes with complementary target DNA. Substitution of aegPNA unit by the designed monomer at the C-terminus was more effective than substitution at N-terminus. The ...