The synthesis and biological evaluation of a novel series of C7 non-basic substituted fluoroquinolones as antibacterial agents

X Huang, D Chen, N Wu, A Zhang, Z Jia, X Li

文献索引：Huang, Xiaoguang; Chen, Dongliang; Wu, Ning; Zhang, Aiqin; Jia, Zhenhua; Li, Xingshu Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4130 - 4133

全文：HTML全文

被引用次数: 18

摘要

A series of non-basic building blocks was synthesized and introduced to the C7 position of the quinolone nucleus 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1, 4-dihydro-1, 8-naphthyridine- 3-carboxylic acid to afford the corresponding fluoroquinolones in 46–85% yield. The antibacterial activity of these new fluoroquinolones was evaluated using a standard broth microdilution technique. The sulfur-containing quinolone, 7-(2-thia-5-azabicyclo [2.2. 1] ...