Structure− activity relationship of (N)-methanocarba phosphonate analogues of 5′-AMP as cardioprotective agents acting through a cardiac P2X receptor

TS Kumar, SY Zhou, BV Joshi…

文献索引：Bichlmaier, Ingo; Kurkela, Mika; Joshi, Tanmaya; Siiskonen, Antti; Rueffer, Tobias; Lang, Heinrich; Suchanova, Bohumila; Vahermo, Mikko; Finel, Moshe; Yli-Kauhaluoma, Jari Journal of Medicinal Chemistry, 2007 , vol. 50, # 11 p. 2655 - 2664

全文：HTML全文

被引用次数: 41

摘要

P2X receptor activation protects in heart failure models. MRS2339 3, a 2-chloro-AMP derivative containing a (N)-methanocarba (bicyclo [3.1. 0] hexane) system, activates this cardioprotective channel. Michaelis− Arbuzov and Wittig reactions provided phosphonate