Synthesis and fate of o-carboxybenzophenones in the biosynthesis of aflatoxin

KM Henry, CA Townsend

文献索引：Henry, Kevin M.; Townsend, Craig A. Journal of the American Chemical Society, 2005 , vol. 127, # 10 p. 3300 - 3309

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被引用次数: 29

摘要

o-Carboxybenzophenones have long been postulated to be intermediates in the oxidative rearrangement of anthraquinone natural products to xanthones in vivo. Many of these Baeyer-Villiger-like cleavages are believed to be carried out by cytochrome P450 enzymes. In the biosynthesis of the fungal carcinogen, aflatoxin, six cytochromes P450 are encoded by the biosynthetic gene cluster. One of these, AflN, is known to be involved in the conversion ...