Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2 (1H) one 5-lipoxygenase pharmacophore: Biological evaluation as dual inhibitors of cyclooxygenases …
MA Chowdhury, KRA Abdellatif, Y Dong, D Das…
文献索引：Chowdhury, Morshed Alam; Abdellatif, Khaled R.A.; Dong, Ying; Das, Dipankar; Suresh, Mavanur R.; Knaus, Edward E. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 23 p. 6138 - 6141
A hitherto unknown class of celecoxib analogs was designed for evaluation as dual inhibitors of the 5-lipoxygenase/cyclooxygenase-2 (5-LOX/COX-2) enzymes. These compounds possess a SO2Me (11a), or SO2NH2 (11b) COX-2 pharmacophore at the para- position of the N1-phenyl ring in conjunction with a 5-LOX N-hydroxypyrid-2 (1H) one iron- chelating moiety in place of the celecoxib C-5 tolyl group. The title compounds 11a–b are ...
