Tetrahedron

Application of organolithium and related reagents in synthesis. Part 7. Synthesis and metallion of 4-methoxypicolin-and 2-methoxyisonicotin-anilides. A useful method …

J Epsztajn, A Bieniek, MW Płotka, K Suwald

文献索引：Epsztajn, Jan; Bieniek, Adam; Plotka, Mieczyslaw W.; Suwald, Krzysztof Tetrahedron, 1989 , vol. 45, # 23 p. 7469 - 7476

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被引用次数: 17

摘要

The synthesis and metallation of 4-methoxypicolin-and 2-methoxyisonicotin-anilides as a way of regiospecific transformation of picolinic and isonicotinic acids into 2, 3, 4- trisubstituted pyridines, is described. The resulted C3-alkylated derivatives underwent smooth acid-catalysed conversion into the corresponding pyridones.