Synthesis and conformational dynamics of tricyclic pyridones containing a fused seven-membered ring

…, L Hitzel, RJ Mortishire-Smith, U Gerhard…

文献索引：Gibson, Karl R.; Hitzel, Laure; Mortishire-Smith, Russell J.; Gerhard, Ute; Jelley, Richard A.; Reeve, Austin J.; Rowley, Michael; Nadin, Alan; Owens, Andrew P. Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9354 - 9360

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被引用次数: 32

摘要

A new synthetic approach to tricyclic pyridones bearing a fused seven-membered ring is described. These compounds exhibit atropisomerism and exist in enantiomeric forms. Chiral HPLC separation of the enantiomers has allowed the rates of racemization to be measured and hence the free energy barrier for flipping the seven-membered ring to be deduced. Introduction of a further element of planar chirality leads to diastereomeric atropisomerism. ...