The syntheses of the natural product anibamine and its three olefin isomers have been achieved concisely and efficiently via highly regio-and stereoselective reactions. The crucial steps included a regioselective palladium-catalyzed alkynylation by Sonogashira coupling and a stereoselective Suzuki coupling. Further conformation analyses and in vitro calcium mobilization studies were carried out to characterize the compounds' biological properties.
