3N-Methylbiphenylsulfonylurea and-carbamate substituted imidazo [4, 5-b] pyridines. Potent antagonists of the ANG II AT 1 receptors

H Heitsch, RHA Becker, HW Kleemann…

文献索引：Heitsch, Holger; Becker, Reinhard H.A.; Kleemann, Heinz-Werner; Wagner, Adalbert Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 4 p. 673 - 678

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被引用次数: 20

摘要

The synthesis and the SAR study of imidazo [4, 5-b] pyridine biphenyl sulfonylureas and- carbamates as highly potent AT1-selective ANG II receptor antagonists are described. Several members of this new class of antagonists efficiently inhibited the ANG II-induced pressor response in pithed rats after iv and intraduodenal (id) administration.