Synthesis of HIV protease inhibitor ABT-378 (Lopinavir)

EJ Stoner, AJ Cooper, DA Dickman…

文献索引：Organic Process Research and Development, , vol. 4, # 4 p. 264 - 269

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被引用次数: 35

摘要

... By this four-step procedure, ABT-378 is produced in 58% overall yield from diamino alcohols 4. Utilizing commonly available reagents and robust reaction conditions, this process is amenable to ... neutralized to pH ≈ 2 with concentrated H 2 SO 4 . The organic layer was ...