Tetrahedron

Baker's yeast mediated reduction of aromatic ring substituted 2-tetralones

P Manitto, G Speranza, D Monti, G Fontana…

文献索引：Manitto, Paolo; Speranza, Giovanna; Monti, Diego; Fontana, Gabriele; Panosetti, Elisa Tetrahedron, 1995 , vol. 51, # 42 p. 11531 - 11546

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被引用次数: 28

摘要

2-Telraloncs mono-and disubstitutcd with methoxy or hydroxy groups in the aromatic ring are hydrogenated to 2-tetralols in good yields by non-fermenting baker's yeast. The prevalent enantioform of the reduction product and its ee were found to depend on the substitution pattern. In one case, ie the biotransformation of 5-mcthoxy-2-tetralone into the corresponding 2-tetralol, an ee≥ 98% was observed. A simple abstract model for ...