Abstract The incubated whole-cell biocatalyst of Pichia minuta JCM 3622 reduced 2-chloro- 1-(3-nitrophenyl) ethanone to provide (R)-2-chloro-1-(3-nitrophenyl) ethanol with 99.2% ee in 87% isolated yield in the presence of Amberlite XAD-7 as a reservoir for the hydrophobic, crystalline and toxic substrate. The product was transformed to (R)-1-(3-hydroxyphenyl)-2- methylaminoethanol (phenylephrine, 1a), a selective α 1-adrenergic receptor agonist, in ...
[Musser, John H.; Kubrak, Dennis M.; Bender, Reinhold H. W.; Kreft, Anthony F.; Nielsen, Susan T.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 2087 - 2093]
