Dog coronary artery adenosine receptor. Structure of the N6-aryl subregion

S Kusachi, RD Thompson, N Yamada…

文献索引：Kusachi,Shozo; Thompson, Robert D.; Yamada, Nobuyuki; Daly, Daniel T.; Olsson, R. A. Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 989 - 996

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被引用次数: 22

摘要

Previous structure-coronary vasoactivity correlations of the N6-alkyladenosine analogues of N6-[(R)-l-phenyl-Z-propylladenosine, 1, support the hypothesis that the coronary artery A2 adenosine receptor contains an N6 region of specialized structure. The part of this receptor region that binds the 2-propyl moiety of 1 determines stereoselectivity and contributes to coronary vasoactivity. The present study uses 92 adenosine analogues containing an aryl ...