Synthesis and evaluation of new ω-borono-α-amino acids as rat liver arginase inhibitors

…, S Vadon-Le Goff, D Mansuy, JL Boucher

文献索引：Busnel, Olivier; Carreaux, Francois; Carboni, Bertrand; Pethe, Stephanie; Goff, Sandrine Vadon-Le; Mansuy, Daniel; Boucher, Jean-Luc Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 7 p. 2373 - 2379

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被引用次数: 24

摘要

Recent studies have demonstrated that arginase plays important roles in pathologies such as asthma or erectile dysfunctions. We have synthesized new ω-borono-α-amino acids that are analogues of the previously known arginase inhibitors S-(2-boronoethyl)-l-cysteine (BEC) and 2-amino-6-boronohexanoic acid (ABH) and evaluated them as inhibitors of purified rat liver arginase (RLA). In addition to the distance between the B (OH) 2 and the ...