Journal of medicinal chemistry

Hypolipidemic activity of indan-1, 3-dione derivatives in rodents

AR Murthy, SD Wyrick, IH Hall

文献索引：Murthy, A. R.; Wyrick, S. D.; Hall, I. H. Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1591 - 1596

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被引用次数: 15

摘要

A series of 2-substituted indan-1, 3-dione derivatives, including alkyl (ClC-5), mono-and disubstituted phenyl, and other 2-aryl derivatives, were tested for hypolipidemic activity of CF, male mice at 20 mg/kg per day. These derivatives reduced both serum cholesterol and triglycerides after 16 days of administration intraperitoneally. 2-(4-Methoxyphenyl) indan-1, 3- dione was one of the more active compounds with 41% reduction of serum cholesterol ...