Tetrahedron letters

Initial synthesis of UK-427,857 (Maraviroc)

…, J Ahman, S Haycock-Lewandowski, BL Stammen…

文献索引：Price, David A.; Gayton, Simon; Selby, Matthew D.; Ahman, Jens; Haycock-Lewandowski, Sarah; Stammen, Blanda L.; Warren, Andrew Tetrahedron Letters, 2005 , vol. 46, # 30 p. 5005 - 5007

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被引用次数: 48

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The initial synthesis of UK-427,857 (Maraviroc) is described including the preparation of 4,4-difluorocyclohexanoic acid and amide coupling utilizing a polymer supported reagent. ... UK-427,857 (Maraviroc) is a potent antagonist of the CCR5 receptor and is currently progressing through phase III ...