Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular …

…, E Barresi, S Di Maro, F Simorini, S Taliani…

文献索引：Sartini, Stefania; Cosconati, Sandro; Marinelli, Luciana; Barresi, Elisabetta; Di Maro, Salvatore; Simorini, Francesca; Taliani, Sabrina; Salerno, Silvia; Marini, Anna Maria; Da Settimo, Federico; Novellino, Ettore; La Motta, Concettina Journal of Medicinal Chemistry, 2012 , vol. 55, # 23 p. 10523 - 10531

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被引用次数: 12

摘要

Diabetes mellitus is the major risk factor for cardiovascular disorders. Aldose reductase, the rate-limiting enzyme of the polyol pathway, plays a key role in the pathogenesis of diabetic complications. Accordingly, inhibition of this enzyme is emerging as a major therapeutic strategy for the treatment of hyperglycemia-induced cardiovascular pathologies. In this study, we describe a series of 5 (6)-substituted benzofuroxane derivatives, 5a–k, m, ...