European journal of medicinal chemistry

Synthesis of some new 4-styryltetrazolo [1, 5-a] quinoxaline and 1-substituted-4-styryl [1, 2, 4] triazolo [4, 3-a] quinoxaline derivatives as potent anticonvulsants

S Wagle, AV Adhikari, NS Kumari

文献索引：Wagle, Shivananda; Adhikari, Airody Vasudeva; Kumari, Nalilu Suchetha European Journal of Medicinal Chemistry, 2009 , vol. 44, # 3 p. 1135 - 1143

全文：HTML全文

被引用次数: 52

摘要

4-Methyltetrazolo [1, 5-a] quinoxaline (3) was prepared by the azide cyclocondensation of 2- chloro-3-methylquinoxaline (2). The reaction of 3 with aromatic aldehydes furnished 4- styryltetrazolo [1, 5-a] quinoxalines (4a–f). Compound 2, on treatment with hydrazine hydrate gave 2-hydrazino-3-methylquinoxaline (5). The ring closure of 5 was achieved by the reaction of orthoesters and trifluoroacetic acid to yield 4-methyl-1-(substituted)[1, 2, 4] ...