Studies related to cephalosporins. Part 2. Displacement reactions on 3??bromomethylcephems with salts of carboxylic acids

M Botta, F De Angelis, I Grgurina…

文献索引：Botta; De Angelis; Grgurina; et al. Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 4 p. 1001 - 1007

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被引用次数: 5

摘要

Abstract The reactivity of Δ 3-and Δ 2-3-bromomethylcephems toward carboxylate nucleophiles has been studied. The Δ 3-bromomethylcephem 1, less reactive than the Δ 2- analogue 4, is converted in high yields into 3-acyl-oxymethyl-3-cephems 2a-d, generally with no isomerization of the double bond, only within a narrow range of conditions. In particular, the Δ 3-7-aminocephalosporanic acid (7-ACA) derivative 2a has been obtained ...