Synthetic Communications

An Improved Procedure for the Synthesis of 4-Oxopimelate-Derived Materials. 1

RJ Pariza, F Kuo, PL Fuchs

文献索引：Pariza, R. J.; Kuo, F.; Fuchs, P. L. Synthetic Communications, 1983 , vol. 13, # 3 p. 243 - 254

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被引用次数: 16

摘要

Abstract In the course of one of our synthetic projects we required efficient access to 4- ethylenedioxy-2-carbomethoxycyclohexanone 6. 2, 4, 5 Synthesis of this material has been traditionally accomplished by conversion of 2-furaldehyde 1 to furylacrylic acid 2 via an Organic Synthesis procedure (90%), 3 followed by treatment of 2 with methanolic HCI to afford dimethyl 4-oxopimelate 3 in reported yields of 60% 4 and 80%. 5 This latter step ...