Facile synthesis of cyclic dipeptides and detection of racemization

T Ueda, M Saito, T Kato, N Izumiya

文献索引：Ueda, Toshihisa; Saito, Morinobu; Kato, Tetsuo; Izumiya, Nobuo Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 2 p. 568 - 572

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被引用次数: 40

摘要

Several cyclic dipeptides were synthesized by refluxing methanolic solution of dipeptide methyl esters in high yield and purity. Cyclic dipeptides prepared by the Fischer method, the Nitecki method, and the present methanol-reflux method were compared with respect to yield and optical purity. The methanol-reflux method usually gave good results. High- performance liquid chromatography was effectively applied to detect racemization.