Tetrahedron letters

Regioselective lithium–halogen exchange and palladium-catalyzed cross-coupling reactions of 2, 4-dihaloquinolines

DL Comins, JM Nolan, ID Bori

文献索引：Comins, Daniel L.; Nolan, Jason M.; Bori, Ibrahim D. Tetrahedron Letters, 2005 , vol. 46, # 39 p. 6697 - 6699

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被引用次数: 34

摘要

Lithium–halogen exchange of 2, 4-dibromoquinolines proceeds regioselectively at C-4 and affords 4-substituted quinolines on quenching with electrophiles. Palladium-catalyzed cross- coupling reactions of 2-bromo-4-iodoquinoline provide 4-substituted 2-bromoquinoline derivatives.