Synthesis of 2-fluoropropenoic acid derivatives

V Tolman, P Špronglová

文献索引：Tolman, Vladimir; Spronglova, Pavla Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 1 p. 319 - 326

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被引用次数: 18

摘要

Abstract A method is described for the synthesis of 2-fluoropropenoic acid esters, amides, and nitrile from the corresponding derivatives of 2-fluoro-3-(4-toluenesulfonyloxy) propanoic acid by heating with potassium phthalimide in vacuo. The free acid Ia and its chloride have also been synthesized. The reactivity of esters and nitrile of acid Ia has been verified by the Michael addition of diethyl acetamidomalonate to these compounds.

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