Synthesis of trifluoromethylthiazoles and their application to azo dyes

K Tanaka, K Nomura, H Oda, S Yoshida…

文献索引：Tanaka, Kiyoshi; Nomura, Kazuto; Oda, Hitoshi; Yoshida, Shouhei; Mitsuhashi, Keiryo Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 4 p. 907 - 911

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被引用次数: 34

摘要

Abstract 3-Bromo-1, 1, 1-trifluoropropan-2-one (2) reacted with thiourea and N- monosubstituted thioureas to give the corresponding 4-trifluoromethylthiazoles, respectively. In the reactions with N, N'-diphenylthiourea and thioamides, the considerably stable intermediates, 4-hydroxy-4-trifluoromethylthiazoline derivatives 7 and 8, were isolated. The reaction of ethyl 2-bromo-4, 4, 4-trifluoro-3-oxobutanoate (4) with thiourea was carried out ...