Stereochemical Studies. LII. Studies on the Stereochemical Courese in Deaminative Bromination of 3, 5-Dichloro-L-tyrosine and in Amination of the Corresponding α- …

K KOGA, T JUANG, S YAMADA

文献索引：Koga,K. et al. Chemical and Pharmaceutical Bulletin, 1978 , vol. 26, # 1 p. 178 - 184

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被引用次数: 4

摘要

It has become apparent that deaminative bromination of 3, 5-dichloro-L-tyrosine (L-4) to the corresponding α-bromo acid ((-)-5) occurs with retention of configuration, and that amination of this bromo acid to the starting amino acid (L-4) occurs also with retention of configuration. The unusual stereochemical course in this amination step was found to be due to the strong neighboring aryl group participation as a phenoxide form.