Metal Free Quick Introduction of Azole in to Azine Nucleus: Acid Catalyzed Reissert-Henze Reaction

A Velavan, D Mondal, S Survase

文献索引：Velavan; Mondal, Dibyendu; Survase, Sachin Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 11 p. 3459 - 3462

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摘要

Imidazole appended heterocycle moieties are commonly encountered in biologically important molecules. Imidazole substituted in 2nd position of pyridine or quinoline moieties are prevalent in the SAR study of most drug discovery programs such as human neutrophil elastase, 1 gastric H+/K+-ATPase inhibitors, 2 NNRTIs (nucleoside Reverse Transcriptase Inhibitors), 3 HIV entry inhibitors, 4 CB1 antagonist5 and AMPA receptors. 6 Further, 2- ...