Structure-activity relationship of 6-methylidene penems bearing 6, 5 bicyclic heterocycles as broad-spectrum β-lactamase inhibitors: evidence for 1, 4-thiazepine …

AM Venkatesan, A Agarwal, T Abe…

文献索引：Journal of Medicinal Chemistry, , vol. 49, # 15 p. 4623 - 4637

全文：HTML全文

被引用次数: 42

摘要

... Journal of Medicinal Chemistry. ... Introduction. Resistance to β-lactam antibiotics in Gram-negative bacteria due to the production of β-lactamases is a serious medical problem with global consequences. β-Lactams are ...