Synthesis of bisaminoacylated pdCpAs and tandemly activated transfer RNAs

M Duca, DJ Maloney, M Lodder, B Wang…

文献索引：Duca, Maria; Maloney, David J.; Lodder, Michiel; Wang, Bixun; Hecht, Sidney M. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 13 p. 4629 - 4642

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被引用次数: 9

摘要

Described herein is the preparation of new bisacylated tRNAs and their participation in protein synthesis. It has been reported that Thermus thermophilus phenylalanyl-tRNA synthetase can introduce two phenylalanine moieties onto the 3′-terminal adenosine of its cognate tRNA. It is also possible to prepare bisactivated tRNAs in vitro; these participate in protein synthesis [Wang, B.; Zhou, J.; Lodder, M.; Anderson, RD; Hecht, SMJ Biol. Chem. ...