MedChemComm

Transformation of a selective factor Xa inhibitor rivaroxaban into a dual factor Xa/thrombin inhibitor by modification of the morpholin-3-one moiety

U Trstenjak, J Ilaš, D Kikelj

文献索引：MedChemComm, , vol. 5, # 2 p. 197 - 202

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被引用次数: 3

摘要

... The first step of rivaroxaban modification towards potential dual antithrombotic compounds II 22 comprised introducing P 4 ... 4 (2R,5′′S)-24 docked into the fXa active site 4 (top) and ... Xa inhibitor rivaroxaban by exploration of SAR regarding the moiety bound at position 2 of the ...