Carbohydrate research

Synthesis of isotopically labeled d-[1′-13 C] ribonucleoside phosphoramidites

Y Saito, A Nyilas, LA Agrofoglio

文献索引：Saito, Yoshio; Nyilas, Agnes; Agrofoglio, Luigi A. Carbohydrate Research, 2001 , vol. 331, # 1 p. 83 - 90

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被引用次数: 16

摘要

The preparation of fully protected labeled diisopropylamino-β-cyanoethyl-[1′-13C] ribonucleoside phosphoramidites with regioisomeric purity is described. We demonstrated in this paper that a regioselective 2′-O-silylation, through a 3′, 5′-O-di-tert- butylsilanediyl protection, has been applied for the synthesis of [1′-13C] ribonucleoside phosphoramidite units. This method allowed us to obtain only the desired 2′-O-silyl-3′- ...