Synthesis of 3-benzyl-2-substituted quinoxalines as novel monoamine oxidase A inhibitors

SY Hassan, SN Khattab, AA Bekhit, A Amer

文献索引：Hassan, Seham Y.; Khattab, Sherine N.; Bekhit, Adnan A.; Amer, Adel Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 6 p. 1753 - 1756

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被引用次数: 57

摘要

A new series of 3-benzyl-2-substituted quinoxalines have been synthesized by means of microwave enhancement of nucleophilic substitution reaction involving the corresponding 2- chloroquinoxaline analogs and substituted amines or hydrazine. The synthesized compounds were evaluated for their monoamine oxidase A and B inhibitory activity by determination of their IC50. All the newly synthesized compounds showed more selective ...