Synthesis of highly functionalized anthraquinones and evaluation of their antitumor activity

…, KM Gericke, I Schuberth

文献索引：Tietze, Lutz F.; Gericke, Kersten M.; Schuberth, Ingrid European Journal of Organic Chemistry, 2007 , # 27 p. 4563 - 4577

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被引用次数: 19

摘要

Abstract Highly functionalized anthraquinones which derive from the natural products mensacarcin, islandicin, and chrysophanol have been efficiently synthesized using a Diels– Alder reaction as key step. The introduction of the proposed pharmacophoric side chain unit has been achieved by an addition of an aryllithium species onto different aldehydes. Furthermore, the antitumor activity of these novel compounds has been studied by the in ...