Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment

SC Mayer, AL Banker, F Boschelli, L Di…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 12 p. 3641 - 3645

全文：HTML全文

被引用次数: 43

摘要

... Bioorganic & Medicinal Chemistry Letters. ... focused library arrays were instrumental in moving these investigations through the Wyeth exploratory medicinal chemistry process. ... 1)]. 8 Along with chemical triage and data-mining, input from structural biology helped to fully ...