Research on Chemical Intermediates

Synthesis of 2-(arylamino) nicotinic acids in high-temperature water

Z Li, S Xiao, R Liang, Z Xia

文献索引：Li, Zhenghua; Xiao, Shangyou; Liang, Ronghui; Xia, Zhining Research on Chemical Intermediates, 2012 , vol. 38, # 7 p. 1691 - 1697

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摘要

Abstract In hydrothermal reactions at 150–180° C, 2-(arylamino) nicotinic acids were synthesized by amination of 2-chloronicotinic acid with aromatic amine derivatives, with potassium carbonate as base. The procedure is efficient, environmentally friendly, and practical, with moderate to excellent yields (up to 98%).