Tetrahedron letters

TMS· OTf-Catalyzed α-bromination of carbonyl compounds by N-bromosuccinimide

SK Guha, B Wu, BS Kim, W Baik, S Koo

文献索引：Guha, Samar Kumar; Wu, Bo; Kim, Beom Soo; Baik, Woonphil; Koo, Sangho Tetrahedron Letters, 2006 , vol. 47, # 3 p. 291 - 293

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被引用次数: 40

摘要

Various carbonyl compounds undergo α-bromination reaction under a mild and practical condition utilizing N-bromosuccinimide (NBS), catalyzed by trimethylsilyl trifluoromethanesulfonate (TMS· OTf). This method is also effective for the side-chain bromination of heteroaromatic carbonyl compounds without the ring brominations.