Tetrahedron

Dual C–H activations of electron-deficient heteroarenes: palladium-catalyzed oxidative cross coupling of thiazoles with azine N-oxides

XP Fu, QQ Xuan, L Liu, D Wang, YJ Chen, CJ Li

文献索引：Fu, Xiao-Pu; Xuan, Qing-Qing; Liu, Li; Wang, Dong; Chen, Yong-Jun; Li, Chao-Jun Tetrahedron, 2013 , vol. 69, # 22 p. 4436 - 4444

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被引用次数: 22

摘要

The palladium-catalyzed, copper-promoted cross-dehydrogenative-coupling (CDC) of electron-deficient thiazoles with azine N-oxides through dual C–H activations was developed. It was found that copper (II) pivalate was an efficient dual-function reagent for the oxidative cross-coupling reactions, playing the roles of both an oxidant and a C–H bond activation promoter. This methodology provides a simple way to construct 2-thiazolyl ...