Tetrahedron: Asymmetry

Novel atropisomeric bisphosphine ligands with a bridge across the 5, 5′-position of the biphenyl for asymmetric catalysis

H Wei, YJ Zhang, F Wang, W Zhang

文献索引：Wei, Hao; Zhang, Yong Jian; Wang, Feijun; Zhang, Wanbin Tetrahedron Asymmetry, 2008 , vol. 19, # 4 p. 482 - 488

全文：HTML全文

被引用次数: 16

摘要

A new type of atropisomeric bisphosphine ligand 2 with a bridge across the 5, 5′-position of the biphenyl has been developed. The axial chirality of this type of ligands can be retained by macrocyclic ring strain produced from 5, 5′-linkage of the biphenyl even without 6, 6′-substituents on the biphenyls. Ligand (R)-2a showed good catalytic activity and enantioselectivity for Rh (I)-catalyzed asymmetric hydrogenation of (Z)-α- ...