Tetrahedron

Pd-catalyzed intramolecular direct arylations at high temperature

P Franck, S Hostyn, B Dajka-Halász, Á Polonka-Bálint…

文献索引：Franck, Philippe; Hostyn, Steven; Dajka-Halasz, Beata; Polonka-Balint, Agnes; Monsieurs, Katrien; Matyus, Peter; Maes, Bert U.W. Tetrahedron, 2008 , vol. 64, # 26 p. 6030 - 6037

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被引用次数: 31

摘要

Pd-catalyzed cyclodehydrohalogenation involving oxidative addition of aromatic C–Br or activated azaheteroaromatic C–Cl bonds and C (sp2)–H activation have been investigated at high reaction temperatures (180–200° C). This allowed the fast (10–30min) synthesis of a variety of azaheteroaromatic ring systems (dibenzo [f, h] phthalazine, dibenzo [f, h] cinnoline, benzofuro [2, 3-d] pyridazine, 5H-pyridazino [4, 5-b] indole, 7H-indolo [2, 3-c] quinoline ...