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Highly efficient and economic synthesis of new substituted amino-bispyridyl derivatives via copper and palladium catalysis

S Gaillard, MK Elmkaddem, C Fischmeister…

文献索引:Gaillard, Sylvain; Elmkaddem, Mohammed Kamal; Fischmeister, Cedric; Thomas, Christophe M.; Renaud, Jean-Luc Tetrahedron Letters, 2008 , vol. 49, # 21 p. 3471 - 3474

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被引用次数: 31

摘要

A convenient route for the synthesis of a variety of amino-bispyridyl compounds is introduced. Bispyridylamines were prepared in three steps from commercially available 2, 6- dibromopyridine, via a copper mediated alkylation followed by two consecutive N-arylation reactions catalyzed by copper and palladium, respectively.