Organic letters

Regiocontrolled synthesis of substituted thiazoles

KJ Hodgetts, MT Kershaw

文献索引：Hodgetts, Kevin J.; Kershaw, Mark T. Organic Letters, 2002 , vol. 4, # 8 p. 1363 - 1365

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被引用次数: 56

摘要

The classical method for the synthesis of thiazoles is the Hantzsch process, in which an α-haloketone is condensed with a thioamide. 5 This method gives excellent yields for simple thiazoles; however, for some substituted examples low yields have been reported as a result of dehalogenation of the α-haloketone during the reaction. 4,6 Notwithstanding the Hantzsch process and other methods, 7 we required a flexible route that would give high yielding and rapid access to ...