Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of methyl groups on the aromatic ring …
S Ferorelli, F Loiodice, V Tortorella, D Conte-Camerino…
文献索引：Ferorelli, Savina; Loiodice, Fulvio; Tortorella, Vincenzo; Conte-Camerino, Diana; De Luca, Anna Maria Farmaco, 2001 , vol. 56, # 3 p. 239 - 246
One or two methyl groups have been introduced on the aromatic ring of two chiral clofibric acid analogs, 2-(4-chloro-phenoxy) propanoic and 2-(4-chloro-phenoxy) butanoic acids. The biological activity of the derivatives obtained (3–6) has been evaluated on the skeletal muscle chloride conductance (gCl). The results confirm the hypothesis of two different sites modulating chloride channel function, an excitatory site that increases channel activity and ...
