Iridium-Catalyzed, Intermolecular Hydroamination of Unactivated Alkenes with Indoles

CS Sevov, J Zhou, JF Hartwig

文献索引：Sevov, Christo S.; Zhou, Jianrong; Hartwig, John F. Journal of the American Chemical Society, 2014 , vol. 136, # 8 p. 3200 - 3207

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被引用次数: 35

摘要

The addition of an N–H bond to an olefin is the most direct route for the synthesis of alkylamines. Currently, intermolecular hydroamination is limited to reactions of a narrow range of reagents containing N–H bonds or activated alkenes, and all the examples of additions to unactivated alkenes require large excesses of alkene. We report intermolecular hydroamination reactions of indoles with unactivated olefins. The reactions occur with as ...