An approach to substituted 4??hydroxypyran??2??ones

ML Ramirez, D Garey, MR Peña

文献索引：Ramirez, Mai-ly; Garey, Donna; Pena, Michael R. Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 5 p. 1657 - 1660

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被引用次数: 8

摘要

Abstract We examined a method for the preparation of 4-hydroxypyran-2-ones in two steps from aryl ketones and ethyl malonyl chloride (or ethyl 2-methylmalonyl chloride). These 4- hydroxypyran-2-ones are useful precursors as they may be transformed in two steps to the 2- methoxypyran-4-ones, which is found in phenoxan—a naturally occurring compound discovered to have anti-HIV activity.