A series of 2-arylamino-5-(indolyl)-1, 3, 4-thiadiazoles 6a–v were prepared and studied for their anticancer activity against selected human cancer cell lines. The reaction of indolylhydrazides 3a–h with a variety of aryl isothiocyanates 4 afforded the key intermediate thiosemicarbazides 5a–v, which upon treatment with acetyl chloride produced the 2- arylamino-5-(indolyl)-1, 3, 4-thiadiazoles 6a–v in good yields. Most of the synthesized ...
