Tetrahedron

Viable and straightforward approach to the preparation of water soluble pyrazol-5-one derivatives through glycoconjugation

R Bianchini, M Bonanni, M Corsi, AS Infantino

文献索引：Bianchini, Roberto; Bonanni, Marco; Corsi, Massimo; Infantino, Angela Simona Tetrahedron, 2012 , vol. 68, # 41 p. 8636 - 8644

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被引用次数: 6

摘要

The synthesis of water soluble pyrazol-5-one azo-dyes has been achieved. 6′- Aminolactosetriacetonide 9 was selected as the key building block to glyconjugate the pyrazole ring at its 3 position via a carboxamide or via a benzeneamide moiety in position 1 of the heterocycle. Diethyl-3-oxopentandionate 2 led eventually to a bicyclic compound, hampering the glyconjugation coupling process. The values of the molar extinction ...