Design, synthesis, and evaluation of aza-peptide epoxides as selective and potent inhibitors of caspases-1,-3,-6, and-8

KE James, JL Asgian, ZZ Li, ÖD Ekici…

文献索引：Journal of Medicinal Chemistry, , vol. 47, # 6 p. 1553 - 1574

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被引用次数: 58

摘要

... Journal of Medicinal Chemistry. ... Chemistry. Our preliminary communication reports the general method used to prepare aza-peptide epoxides. 35 The procedure involves coupling a substituted peptidyl hydrazide (21 ...