Amino acids

A novel radiofluorinated agouti-related protein for tumor angiogenesis imaging

…, H Liu, Z Miao, FV Cochran, Y Liu, M Tian, JR Cochran…

文献索引：Jiang, Han; Moore, Sarah J.; Liu, Shuanglong; Liu, Hongguang; Miao, Zheng; Cochran, Frank V.; Liu, Yang; Tian, Mei; Cochran, Jennifer R.; Zhang, Hong; Cheng, Zhen Amino Acids, 2013 , vol. 44, # 2 p. 673 - 681 Title/Abstract Full Text View citing articles Show Details Liu, Hongguang; Liu, Shuanglong; Miao, Zheng; Jiang, Han; Deng, Zixin; Hong, Xuechuan; Cheng, Zhen Molecular Pharmaceutics, 2013 , vol. 10, # 9 p. 3384 - 3391

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被引用次数: 8

摘要

Abstract A novel protein scaffold based on the cystine knot domain of the agouti-related protein (AgRP) has been used to engineer mutants that can bind to the α v β 3 integrin receptor with high affinity and specificity. In the current study, an 18 F-labeled AgRP mutant (7C) was prepared and evaluated as a positron emission tomography (PET) probe for imaging tumor angiogenesis. AgRP-7C was synthesized by solid phase peptide synthesis ...