... (1) (a) Lipinski, C. A,; Hutson NJ In Annual Reports in Medicinal Chemistry; Bailey, DM, Ed.; Academic: New York, 1984; Vol. 19, Chapter 17. ... The layers were separated, and the organic phase was washed with water (4 X 400 mL) followed by brine and dried. ... J. Org. Chem., Vol. ...