Tetrahedron

Synthesis of novel halopyridinylboronic acids and esters. Part 3: 2, or 3-Halopyridin-4-yl-boronic acids and esters

A Bouillon, JC Lancelot, V Collot, PR Bovy, S Rault

文献索引：Bouillon, Alexandre; Lancelot, Jean-Charles; Collot, Valerie; Bovy, Philippe R; Rault, Sylvain Tetrahedron, 2002 , vol. 58, # 22 p. 4369 - 4373

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被引用次数: 78

摘要

This paper describes a general method for the synthesis and the isolation of novel 2, or 3- halopyridin-4-yl-boronic acids and esters 12–14, 18–20. These compounds are prepared taking in account a regioselective halogen–metal exchange using nBuLi or directed ortho- metalation using LDA and subsequent quenching with triisopropylborate starting from appropriate mono or dihalopyridines. All substrates studied to date provided a single ...